ACETYL-CHYMOTRYPSIN
نویسندگان
چکیده
منابع مشابه
Analogues of acetyl chymotrypsin.
Previous papers (1, 2) have reported the acylation of chymotrypsin with several nitrophenyl acetates. It was of obvious interest to test the behavior of nitrophenyl esters of other acids in the same connection. It now appears that chymotrypsin may be acylated by a number of acids differing considerably from acetic acid in structure. Beneoyl and salicyl chymotrypsins were prepared and found to r...
متن کاملAcetyl chymotrypsin and its reaction with ethanol.
A short report has recently been made (1) concerning the preparation of an acetyl derivative of chymotrypsin containing a single acetyl group of relatively high reactivity. The reaction, which may be carried out by any of several nitrophenyl acetates, begins with a rapid initial liberation of the free nitrophenol in practically mole for mole proportions to the total chymotrypsin present. Therea...
متن کاملThe hydrolysis of N-benzoyl-DL-tyrosylglycinamide, N-acetyl-L-tyrosylglycinamide, and N-acetyl-DL-tyrosylglycinamide by chymotrypsin.
Contrary to the report of Bergmann and Fruton (1) the L peptide present in aqueous solutions of N-benzoyl-DL-tyrosylglycinamide, prepared by two independent methods, is rapidly hydrolyzed by crystalline chymotrypsin. At 40” and pH 7.8 in a 0.00344 M solution’ of the DL mixture the L component is hydrolyzed as rapidly as in a 0.00172 M solution of the L peptide (Table I). Because of the relative...
متن کاملSpecificity of chymotrypsin B.
Brown, Shupe, and Laskowski (1) have described the isolation, from beef pancreas, of a crystalline proteolytic enzyme which they have named “activated protein B” or “chymotrypsin B.” Through the kindness of Dr. Laskowski who provided us with a 4 times recrystallized sample of this enzyme, it was possible to examine its action on a series of synthetic peptides and peptide derivatives. The data p...
متن کاملStructure and Mechanism of Chymotrypsin
Our understanding of enzyme catalysis has advanced steadily since x-ray diffraction results gave the first detailed information about the architecture of an enzyme molecule 10 years ago. The mechanism of chymotrypsin is probably understood in more detail than any other enzyme a t the present time. As enzymes go, it is a very simple one, and it has proved accessible to study by a wide range of d...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1955
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.41.4.190